Evidence that a single monolayer tubulin-GTP cap is both necessary and sufficient to stabilize microtubules.
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Evidence that a single monolayer tubulin-GTP cap is both necessary and sufficient to stabilize microtubules.
Evidence that 13 or 14 contiguous tubulin-GTP subunits are sufficient to cap and stabilize a microtubule end and that loss of only one of these subunits results in the transition to rapid disassembly(catastrophe) was obtained using the slowly hydrolyzable GTP analogue guanylyl-(a,b)-methylene-diphosphonate (GMPCPP). The minus end of microtubules assembled with GTP was transiently stabilized aga...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1996
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.7.4.663